CALL FOR PAPERS Renal Hypoxia Interactions between HIF-1 and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease
نویسندگان
چکیده
Hui Li,* Joseph Satriano,* Joanna L. Thomas, Satoshi Miyamoto, Kumar Sharma, Núria M. Pastor-Soler, Kenneth R. Hallows, and Prabhleen Singh Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Division of Nephrology and Hypertension, Department of Medicine, University of California and Veterans Affairs San Diego Healthcare System, San Diego, California; and Center for Renal Translational Medicine, University of California, San Diego, California
منابع مشابه
Interactions between HIF-1α and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease.
Renal hypoxia contributes to chronic kidney disease (CKD) progression, as validated in experimental and human CKD. In the early stages, increased oxygen consumption causes oxygen demand/supply mismatch, leading to hypoxia. Hence, early targeting of the determinants and regulators of oxygen consumption in CKD may alter the disease course before permanent damage ensues. Here, we focus on hypoxia ...
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Tubulointerstitial hypoxia plays a critical role in the pathogenesis of kidney injury, and hypoxia-inducible factor (HIF)-1 is a master regulator of cellular adaptation to hypoxia. Aside from oxygen molecules, factors that modify HIF-1 expression and functional operation remain obscure. Therefore, we sought to identify novel HIF-1-regulating genes in kidney. A short-hairpin RNA library consisti...
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تاریخ انتشار 2015